421 London - Liverpool

Operated by National Express. First bus 01:45, last bus 02:00. 2 journeys on weekdays. Fares: set by the operatormore.

Next towards Liverpool from Victoria Coach Station (north-east bound):

Next towards Victoria from Liverpool ONE Bus Station (Stand 1):

Night bus — overnight departures 01:45–03:35. Every night. Nights are the night you set out on, so a 01:30 bus on Saturday morning counts as Friday. All night buses.

Wanted a different 421? 4 other bus routes are numbered 421 elsewhere in the UK — see every 421 bus timetable by area.

Timetable

Each column is one journey, headed by the time it sets off. Times are shown at the route's main timing stops — buses serve all stops in between. Switch a table to All stops for every stop it calls at, or open a stop's own page for live departures there.

This is a long-distance coach, not a local bus — the £3 England fare cap doesn't apply, and neither do local bus passes. National Express sets its own fares and prices by demand, so booking ahead is usually far cheaper than paying on the day.

Christmas & bank holidays

These dates are not the usual timetable for the day they fall on — they come from the operator’s own published calendar. Everything above is an ordinary week.

Route map

All stops on route 421

Towns & areas on this route

Frequently asked questions

What time is the first 421 coach?

The first 421 departure on weekdays leaves at 01:45 (check the full timetable below for your stop, as times vary along the route — weekend times can differ).

What time is the last 421 coach?

The last 421 on weekdays leaves its first stop at 02:00. Always check the timetable for your specific stop — later stops are reached after this time.

How much does the 421 coach cost?

This is a long-distance coach service, so the England £3 bus fare cap does not apply — nor do local bus tickets or passes. Coach operators set their own fares and price by demand, so booking further ahead is usually much cheaper than buying on the day.

Who runs the 421 coach?

The 421 is operated by National Express.

Timetable data from National Express via the DfT Bus Open Data Service (West Midlands feed). National Express last updated their Bus Open Data publications on 12 August 2026. Check before you travel — services can change at short notice.