421 London - Liverpool
Operated by National Express. First bus 01:45, last bus 02:00. 2 journeys on weekdays. Fares: set by the operator — more.
Night bus — overnight departures 01:45–03:35. Every night. Nights are the night you set out on, so a 01:30 bus on Saturday morning counts as Friday. All night buses.
Wanted a different 421? 4 other bus routes are numbered 421 elsewhere in the UK — see every 421 bus timetable by area.
Each column is one journey, headed by the time it sets off. Times are shown at the route's main timing stops — buses serve all stops in between. Switch a table to All stops for every stop it calls at, or open a stop's own page for live departures there.
Christmas & bank holidays
These dates are not the usual timetable for the day they fall on — they come from the operator’s own published calendar. Everything above is an ordinary week.
- Christmas Day — Friday, 25 December 2026 No buses in the timetable the operator has published so far. Festive timetables are often published only a few weeks ahead, so check again nearer the date.
- Monday, 28 December 2026 towards Liverpool: 1 journey, first 02:00
Route map
All stops on route 421
421 towards Liverpool
All 7 stops
- Victoria Coach Station (north-east bound) Belgravia
- Milton Keynes Coachway (Bay 4) Brook Furlong
- Birmingham Coach Station (Stand 8) Digbeth
- Manchester Airport The Station (Stand B) Manchester Airport
- Manchester Central Coach Station Manchester City Centre
- Broadgreen Interchange (Stop A) Old Swan
- Liverpool ONE Bus Station (Stand 1) Liverpool
421 towards Victoria
All 7 stops
- Liverpool ONE Bus Station (Stand 1) Liverpool
- Broadgreen Interchange (Stop D) Oak Vale Park
- Manchester Central Coach Station Manchester City Centre
- Birmingham Coach Station (Stand 8) Digbeth
- Milton Keynes Coachway (Bay 4) Brook Furlong
- Marble Arch (Stop RH) Marble Arch
- London Victoria Coach Station Arrivals (westbound) Victoria
Towns & areas on this route
Frequently asked questions
What time is the first 421 coach?
The first 421 departure on weekdays leaves at 01:45 (check the full timetable below for your stop, as times vary along the route — weekend times can differ).
What time is the last 421 coach?
The last 421 on weekdays leaves its first stop at 02:00. Always check the timetable for your specific stop — later stops are reached after this time.
How much does the 421 coach cost?
This is a long-distance coach service, so the England £3 bus fare cap does not apply — nor do local bus tickets or passes. Coach operators set their own fares and price by demand, so booking further ahead is usually much cheaper than buying on the day.
Who runs the 421 coach?
The 421 is operated by National Express.
Timetable data from National Express via the DfT Bus Open Data Service (West Midlands feed). National Express last updated their Bus Open Data publications on 12 August 2026. Check before you travel — services can change at short notice.