🚌 Bus from Preston City Centre to Manchester City Centre
3 direct routes · about 80 min · first bus 22:35, last bus 22:35 (weekdays).
Direct routes
| Route | Operator | Journey time | Weekday journeys | First | Last | Board at |
|---|---|---|---|---|---|---|
| 424 | National Express | ~80 min | 1 | 22:35 | 22:35 | Bus Station (Stand A) |
| 181 | National Express | ~55 min | 1 | 03:20 | 03:20 | Bus Station (Stand A) |
| UK030 | FlixBus | ~75 min | 1 | 14:15 | 14:15 | Bus Station (Stand A) |
Times are for the first boarding point in Preston City Centre on each route's weekday timetable — open the route for the full timetable, live map and every stop.
Frequently asked questions
Which bus goes from Preston City Centre to Manchester City Centre?
3 routes run directly from Preston City Centre to Manchester City Centre: the 424 (National Express), the 181 (National Express), the UK030 (FlixBus).
How long does the bus take from Preston City Centre to Manchester City Centre?
Around 80 minutes on the 424, depending on time of day and traffic.
What time is the first and last bus from Preston City Centre to Manchester City Centre?
On weekdays the first direct bus (the 424) leaves around 22:35 and the last around 22:35. Check the route timetable for weekends.
How much is the bus from Preston City Centre to Manchester City Centre?
Fares on this journey are set by the operator — the England fare cap doesn't apply in Scotland. Under-22s, over-60s and eligible disabled passengers travel free with a National Entitlement Card.