Bus from Manchester City Centre to Hamilton (South Lanarkshire)
2 direct routes · about 280 min · first and last bus 15:10 (weekdays); night service 181 runs at 01:35.
Next buses to Hamilton (South Lanarkshire) as of 12:28
Scheduled times at the boarding stop in Manchester City Centre, from the operators' timetables — they update automatically. Open the stop for live tracking.
Direct routes
| Route | Operator | Journey time | Weekday journeys | Days | First | Last | Board at | Get off at | Calls at |
|---|---|---|---|---|---|---|---|---|---|
| 590 | National Express | ~280 min | 2 | Sat 2 · Sun 2 | 15:10 | 15:10 | Manchester Central Coach Station | Bus Station (stance 14) | Penrith & Carlisle |
| 181 | National Express | ~285 min | 1 | Sat 1 · Sun 1 | 01:35 | 01:35 | Manchester Central Coach Station | Bus Station (stance 14) | Preston, Lancaster, Tebay & Carlisle |
Times are for the first boarding point in Manchester City Centre on each route's weekday timetable — open the route for the full timetable, live map and every stop.
The same number runs elsewhere in the UK — see every 590 bus or 181 bus timetable.
Frequently asked questions
Which bus goes from Manchester City Centre to Hamilton?
2 routes run directly from Manchester City Centre to Hamilton: the 590 (National Express), the 181 (National Express). The most frequent is the 590, twice each weekday — board at Manchester Central Coach Station and get off at Bus Station (stance 14), about 280 minutes.
How long does the bus take from Manchester City Centre to Hamilton?
Around 280 minutes on the 590, depending on time of day and traffic. It calls at Penrith, Carlisle on the way.
What time is the first and last bus from Manchester City Centre to Hamilton?
On weekdays the first and last direct bus leaves around 15:10 — and night service 181 runs at 01:35. Check the route timetables for weekends.
How much is the bus from Manchester City Centre to Hamilton?
This is a long-distance coach service, so the England £3 bus fare cap does not apply — nor do local bus tickets or passes. Coach operators set their own fares and price by demand, so booking further ahead is usually much cheaper than buying on the day.